Classical diphtheria caused by Corynebacterium ulcerans in Germany: amino acid sequence differences between diphtheria toxins from Corynebacterium diphtheriae and C. ulcerans.

نویسندگان

  • Andreas Sing
  • Suse Bierschenk
  • Jürgen Heesemann
چکیده

2 Ser Asn Asn Asn 14 Leu Ile Leu Leu 22 Ser Ser Leu Leu 31 Val Asp Val Val 67 Thr Ala Thr Ala 116 Val Ile Ile Ile 183 Ala Ala Glu Glu 210 Ala Ser Ser Ser 233 Val Ala Ala Ala 262 Thr Ile Thr Thr 277 Gln Gln Arg Gln 294 Thr Val Val Val 296 Pro Ser Ser Ser 305 Ala Ser Ser Ser 314 Ile Val Val Val 317 Glu Lys Lys Lys 378 Ile Leu Leu Leu 415 Leu Val Val Val 417 Asp Gly Gly Gly 421 Val Ala Ala Ala 432 Arg Lys Lys Lys 491 Gly Asp Asp Asp 492 Asp Ala Ala Ala 493 Val Thr Thr Thr 500 Ser Thr Thr Thr 518 Arg Arg Thr Arg 527 Asn Asp Asp Asp 529 Ile Thr Thr Thr 530 Ser Pro Pro Pro 531 Ser Leu Leu Leu 532 Asp Ser Ser Ser 535 Gly Asp Asp Asp 556 Phe Ala Ala Ala 558 Ile Val Val Val

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Rapid detection and molecular differentiation of toxigenic Corynebacterium diphtheriae and Corynebacterium ulcerans strains by LightCycler PCR.

The systemic symptoms of diphtheria are caused by the tox-encoded diphtheria toxin (DT) which is produced by toxigenic Corynebacterium spp. Besides the classical agent C. diphtheriae, the zoonotic pathogen C. ulcerans has increasingly been reported as an emerging pathogen for diphtheria. The reliable detection of toxigenic Corynebacterium spp. is of substantial importance for both diphtheria su...

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Nontoxigenic tox-bearing Corynebacterium ulcerans Infection among Game Animals, Germany

Corynebacterium ulcerans may cause diphtheria in humans and caseous lymphadenitis in animals. We isolated nontoxigenic tox-bearing C. ulcerans from 13 game animals in Germany. Our results indicate a role for game animals as reservoirs for zoonotic C. ulcerans.

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عنوان ژورنال:
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

دوره 40 2  شماره 

صفحات  -

تاریخ انتشار 2005